Sustained release microspheres offer advantages like limiting fluctuation within therapeutic range, reducing side effects and improving patient compliance. These also enhance therapeutic efficacy as well as bioavailability of the drug. In the present work ethyl cellulose was used as polymer for formulation of microspheres of antipsychotic agent paliperidone. Emulsion solvent diffusion technique was employed for preparing microspheres by using liquid paraffin as a continuous phase. The prepared microspheres were evaluated for production yield, particle size, drug content, encapsulation efficiency, surface morphology and in vitro drug release. Dissolution study revealed drug release from the microspheres was affected by drug-polymer ratio.
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